Researchers at Bar-Ilan University have increased the life expectancy of mice by 30% using the SIRT6 protein that is involved in regulating many biological processes, such as aging, obesity, and insulin resistance.
Prof. Haim Cohen, director of the Sagol Healthy Human Longevity Center at Bar-Ilan University, focuses much of his research on the SIRT6 protein.
In a study just published in the journal Nature Communications, an international team led by Cohen and his doctoral student Asael Roichman; together with Prof. Rafael de Cabo, of the National Institute on Aging at the National Institutes of Health; Prof. Manuel Serrani, of the Institute for Research in Biomedicine in Barcelona; and Prof. Eyal Gottlieb from the Technion-Israel Institute of Technology, report that transgenic mice express high levels of the SIRT6 gene, and show that their life expectancy can be increased by an average of 30% in both males and females.
The mice also exhibited significant improvement in overcoming a variety of age-related diseases, such as cancer and blood disorders. Beyond this, they were able to conduct the same level of vigorous activity as young mice, and didn’t become frail.
Through a variety of biochemical methods and metabolic analyses the researchers deciphered the mechanism through which SIRT6 acts as a type of “fountain of youth,” facilitating healthy aging. They showed that older animals lose the ability to generate energy in the absence of external energy sources, such as a short fast. On the other hand, the engineered mice maintained an enhanced energy generation capacity from other storage, such as the breakdown of fats and lactic acid. By doing so, they created sugar utilized for energy in muscle and specifically in the brain.
“This discovery, combined with our previous findings, shows that SIRT6 controls the rate of healthy aging,” said Cohen, of Bar-Ilan University’s Mina and Everard Goodman Faculty of Life Sciences. “If we can determine how to activate it in humans, we will be able to prolong life, and this could have enormous health and economic implications.”
Cohen’s lab currently is developing methods for extending healthy life based on these findings.