Israeli Scientists Find How Bacteria Switch on Infection Genes
Israeli scientists have identified a critical mechanism bacteria use to activate disease-causing genes, offering new possibilities for understanding and potentially preventing infections, the Hebrew University of Jerusalem announced Sunday.
The research, published Wednesday in Nature Communications, reveals that the bacterial protein carbon storage regulator A (CsrA) forms droplet-like structures inside bacterial cells, functioning like a “switchboard operator” within a temporary control center. This process helps bacteria adapt to their environment and determine whether to initiate an infection or remain harmless.
Using fluorescent markers, the researchers tracked the formation of these droplets under conditions similar to those found in the human gut. The droplets contain key molecules that regulate genetic activity, according to the university’s statement.
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The team also found evidence suggesting this genetic control system may be common across many bacterial species, not just a single type. This could broaden the understanding of how different pathogens trigger infections in humans and animals.
CsrA has long been known as a major regulator in bacterial cells, but this study is among the first to document its role in forming dynamic control centers that influence virulence.
The discovery may open new research paths for designing drugs that disrupt this mechanism, potentially stopping infections before they take hold.
Hebrew University, consistently ranked among the top academic institutions in Israel, has a strong reputation for breakthroughs in microbiology and infectious disease research.
